Pineapple Express is a sativa-dominant hybrid strain made by crossing Trainwreck with Hawaiian. Pineapple Express produces long-lasting energetic effects that you can feel right away. The best time to smoke Pineapple Express is in the morning, afternoon, or early evening hours. This strain packs a punch with bright citrus notes infused with pineapple and earthy pine. Pineapple Express relieves symptoms associated with depression, pain, and fatigue.